To compare the predictions of the models to the observed values of ?ln(?_S) for each bin, we corrected for the possible effect on ?_S of differences among bins in K_S (15). The regression coefficient for ?ln(?_S) on K_S was estimated by dividing the multiple regression coefficient for ?_S on K_S for the unbinned data by the mean of K_S. We then multiplied this regression coefficient by the difference between mean K_S for a bin and the mean of K_S over all bins, and adding the product to ?ln(?_S) for the bin. We also applied this procedure to the crossing-over rate, because this also had a substantial effect on ?_S (SI Appendix, Table S1); although other variables had significant multiple regression coefficients, the effect sizes were small, with the exception of Fop, and they were thus ignored. In Discussion, we provide reasons for disregarding the effect of Fop.

New combined effects of BGS and you may SSWs was in fact modeled from the a amendment of your own conclusion model discussed over, utilising the are not produced assumption one to sweeps was good enough unusual you to definitely the effects of various sweeps toward synonymous webpages assortment is handled once the independent of each almost every other (fourteen, 62), and that BGS effects is actually independent from sweep effects (step three, 14, 63) (Si Appendix, area cuatro, Eq. (more…)